Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2)

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C20orf36

Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2)
Comparison of the Cullin binding properties of PCMTD2 mutants M5, M6, M7, and M8, all of which bound Elongin C, suggested that the conserved hydrophobic residue, Val, at the N terminus of the PCMTD2 Cul5-box is important for Cul5 binding, whereas the conserved (Y/F) (L/I) residues at the C terminus are much less important.
PCMTD2 mutant M7, in which the N-terminal Val remained unchanged but the four C-terminal residues of the Cul5-box were replaced by the four C-terminal residues of the KLHDC2 Cul2-box, bound Cul5 similarly to wild type PCMTD2. In contrast, PCMTD2 mutants M5, M6, and M8, in which various combinations of these residues plus the N-terminal Val were mutated to residues found in the Cul2-box of KLHDC2, failed to bind either Cul5 or Cul2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein L-Isoaspartate-O-Methyltransferase Domain Containing Protein 2 (PCMTD2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]