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Ovo Like Protein 2 (OVOL2)

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ZNF339; Zinc Finger Protein 339; Transcription factor Ovo-like 2

Ovo Like Protein 2 (OVOL2)
CCC T348
HGNC 15804
MGI 1338039
PubMed 24124593
RGD 1306130
UniProt Q9BRP0
Ovol2 belongs to the Ovo family of evolutionarily conserved zinc finger transcription factors that act downstream of key developmental signaling pathways including Wg/Wnt and BMP/TGF-beta. Ovol2 expression in the basal layer of epidermis, where epidermal stem/progenitor cells reside. Ovol2 depletion also accelerates extracellular signal-induced terminal differentiation in two- and three-dimensional culture models.
Ovol2 directly represses two critical downstream targets, c-Myc and Notch1, thereby suppressing keratinocyte transient proliferation and terminal differentiation, respectively. These findings shed light on how an epidermal cell maintains a proliferation-competent and differentiation-resistant state.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ovo Like Protein 2 (OVOL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ovo Like Protein 2 (OVOL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ovo Like Protein 2 (OVOL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ovo Like Protein 2 (OVOL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ovo Like Protein 2 (OVOL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ovo Like Protein 2 (OVOL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ovo Like Protein 2 (OVOL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ovo Like Protein 2 (OVOL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ovo Like Protein 2 (OVOL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ovo Like Protein 2 (OVOL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ovo Like Protein 2 (OVOL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ovo Like Protein 2 (OVOL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ovo Like Protein 2 (OVOL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ovo Like Protein 2 (OVOL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ovo Like Protein 2 (OVOL2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice."Genomics 80:319-325(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1."J. Biol. Chem. 284:29125-29135(2009) [PubMed] [Europe PMC] [Abstract]
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]