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MMS19 Nucleotide Excision Repair Homolog (MMS19)

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MET18; MMS19L

MMS19 Nucleotide Excision Repair Homolog (MMS19)
CCC T080
HGNC 13824
PubMed 23150669
UniProt Q96T76
Wiki MMS19
MMS19 is required for NER and Pol II transcription, but its precise role in each process is unknown. The human MMS19 gene originates multiple splice variants, some of which may encode distinct MMS19 protein isoforms. MMS19 splice variants are conserved across species and are functionally distinct. Expression of human MMS19 splice variants in mms19-deleted yeast cells produced unique patterns of thermosensitivity and ultraviolet radiation-sensitivity that point to three MMS19 structural domains with distinct in vivo functions. MMS19 polypeptides lacking domain A are able to fulfill the role of full-length MMS19 in NER but not in transcription. MMS19 polypeptides lacking part of domain B are efficient in transcription but not in NER. MMS19 polypeptides lacking domain C (HEAT repeats) are unable to fulfill either function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MMS19 Nucleotide Excision Repair Homolog (MMS19) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MMS19 Nucleotide Excision Repair Homolog (MMS19) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MMS19 Nucleotide Excision Repair Homolog (MMS19) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MMS19 Nucleotide Excision Repair Homolog (MMS19) CLIA Kit Customized Service Offer
n/a ELISA Kit for MMS19 Nucleotide Excision Repair Homolog (MMS19) ELISA Kit Customized Service Offer
  1. "Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases."Nucleic Acids Res. 28:4506-4513(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor."J. Biol. Chem. 276:23962-23968(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant."Nucleic Acids Res. 29:1884-1891(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation."Mol. Cell 39:632-640(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity."Science 337:195-199(2012) [PubMed] [Europe PMC] [Abstract]
  13. "MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism."Science 337:243-245(2012) [PubMed] [Europe PMC] [Abstract]