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Transmembrane Protein 9B (TMEM9B)

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C11orf15

Transmembrane Protein 9B (TMEM9B)
CCC S934
HGNC 1168
MGI 1915254
PubMed 18541524
RGD 1310775
UniProt Q9NQ34
The intracellular signaling pathway by which TNF induces its pleiotropic actions is well-characterized and includes unique components, as well as modules shared with other signaling pathways. TMEM9B as an important component of TNF signaling and which is a module shared with the IL-1β and Toll-like receptor (TLR) pathways. is a glycosylated protein localized in membranes of the lysosome and partially in early endosomes. The expression of TMEM9B is required for the production of proinflammatory cytokines induced by TNF, IL-1β, and TLR ligands, but not for apoptotic cell death triggered by TNF or Fas ligand. TMEM9B is essential in TNF activation of both the NF-κB and MAPK pathways.TMEM9B is a key component of inflammatory signaling pathways and suggest that endosomal or lysosomal compartments regulate these pathways.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 9B (TMEM9B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 9B (TMEM9B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 9B (TMEM9B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 9B (TMEM9B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 9B (TMEM9B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 9B (TMEM9B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 9B (TMEM9B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 9B (TMEM9B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 9B (TMEM9B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 9B (TMEM9B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 9B (TMEM9B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 9B (TMEM9B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 9B (TMEM9B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 9B (TMEM9B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 9B (TMEM9B) ELISA Kit Customized Service Offer
  1. "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7."Cytogenet. Cell Genet. 93:284-290(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways."J. Biol. Chem. 283:21487-21494(2008) [PubMed] [Europe PMC] [Abstract]