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Solute Carrier Family 6, Member A13 (SLC6A13)

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GAT2; Sodium And Chloride Dependent GABA Transporter 2

Solute Carrier Family 6, Member A13 (SLC6A13)
CCC S932
HGNC 11046
MGI 95629
PubMed 22932902
RGD 620788
UniProt Q9NSD5
Hypotaurine uptake into rat placental brush border membrane vesicles and HEK293 cells expressing mouse was measured using LC-MS/MS. GABA at 100 μM significantly inhibit hypotaurine uptake, although taurine (100 μM) and betaine (2 mM) didn't inhibit it. These characteristics were comparable with characteristics of Slc6a13/GAT-2 and Slc6a11/GAT-3, rather than Slc6a1/GAT-1, Slc6a12 /BGT-1 and Slc6a6/TauT. Slc6a13 expression in rat placenta, although Slc6a11 was not detected. Hypotaurine uptake into HEK293 cells expressing mouse Slc6a13 was significantly higher than that into mock cells, and the inhibitory characteristics of hypotaurine uptake via mouse Slc6a13 was similar to into BBMVs. Ezrin expression in placenta is involved in the maintenance of hypotaurine concentration in fetus during the fetal development and Slc6a13 plays the role.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 6, Member A13 (SLC6A13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 6, Member A13 (SLC6A13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 6, Member A13 (SLC6A13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 6, Member A13 (SLC6A13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 6, Member A13 (SLC6A13) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 6, Member A13 (SLC6A13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 6, Member A13 (SLC6A13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 6, Member A13 (SLC6A13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 6, Member A13 (SLC6A13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 6, Member A13 (SLC6A13) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 6, Member A13 (SLC6A13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 6, Member A13 (SLC6A13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 6, Member A13 (SLC6A13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 6, Member A13 (SLC6A13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 6, Member A13 (SLC6A13) ELISA Kit Customized Service Offer
  1. "Sequence and chromosomal assignment of a human novel cDNA: similarity to gamma-aminobutyric acid transporter."Can. J. Physiol. Pharmacol. 79:977-984(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2."J. Biol. Chem. 282:19331-19341(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "High selectivity of the gamma-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach."J. Biol. Chem. 287:37745-37756(2012) [PubMed] [Europe PMC] [Abstract]