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Solute Carrier Organic Anion Transporter Family, Member 1A3 (SLCO1A3)

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Oatp1a3; Slc21a4; OAT-K; Solute Carrier Family 21 Member 1; Sodium-Independent Organic Anion Transporter K1

Solute Carrier Organic Anion Transporter Family, Member 1A3 (SLCO1A3)
CCC S901
PubMed 21606417
RGD 621387
UniProt P70502
SLCO1A3, Belongs to the organo anion transporter (TC 2.A.60) family.Contains 1 Kazal-like domain. Tissue specificity All isoforms are detected in kidney, and many are kidney specific. Isoforms 2 and 13 are also detected in liver. Isoforms 4 and 9/K4 are ubiquitous, but isoform 9/K13 is kidney specific. Isoforms 5 and 14 are detected in all tissues tested, with the exception of pancreas and spleen. Isoforms 11 and 15 are detected in kidney, pancreas and testis. Isoform 7 is detected in kidney, liver, testis and spleen.
Mediates the Na+-independent transport of organic anions such as methotrexate, taurocholate, folate and prostaglandin E2. May contribute to renal secretion and/or reabsorption of hydrophobic anionic compounds. Mediates renal clearance of methotrexate from the blood.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Organic Anion Transporter Family, Member 1A3 (SLCO1A3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1A3 (SLCO1A3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1A3 (SLCO1A3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Organic Anion Transporter Family, Member 1A3 (SLCO1A3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Organic Anion Transporter Family, Member 1A3 (SLCO1A3) ELISA Kit Customized Service Offer
  1. "Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney."J. Biol. Chem. 271:20719-20725(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney."Mol. Pharmacol. 55:743-752(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and tissue-specific expression of spliced variants of the rat organic anion transporter (rOAT-K)."DNA Seq. 13:15-25(2002) [PubMed] [Europe PMC] [Abstract]