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COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A)

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CSN7A; Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a

COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A)
CCC S846
HGNC 16758
MGI 1349400
RGD 1310070
UniProt Q9UBW8
Wiki COPS7A
COPS7A, Belongs to the CSN7/EIF3M family. Widely expressed. Expressed at high level in brain, heart and skeletal muscle. Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) CLIA Kit Customized Service Offer
n/a ELISA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) CLIA Kit Customized Service Offer
n/a ELISA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) CLIA Kit Customized Service Offer
n/a ELISA Kit for COP9 Constitutive Photomorphogenic Homolog Subunit 7A (COPS7A) ELISA Kit Customized Service Offer
  1. "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression."Biochem. J. 366:79-86(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits."FASEB J. 12:469-478(1998) [PubMed] [Europe PMC] [Abstract]
  5. "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system."EMBO J. 20:1630-1639(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome."Science 292:1382-1385(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome."FEBS Lett. 527:15-21(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage."Cell 113:357-367(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome."EMBO J. 22:1302-1312(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry."J. Proteome Res. 7:4914-4925(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]