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Cullin 6 (CUL6)

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Cullin 6 (CUL6)
CCC S842
UniProt Q21346
CUL6 encodes a member of the cullin family that may physically interact with SKR-3; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (729 aa)
Cullins are a family of hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). Cullins are found throughout eukaryotes. Humans express seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), each forming part of a multi-subunit ubiquitin complex. Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF), play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms.

Organism species: Caenorhabditis elegans

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cullin 6 (CUL6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cullin 6 (CUL6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cullin 6 (CUL6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cullin 6 (CUL6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cullin 6 (CUL6) ELISA Kit Customized Service Offer
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis."Curr. Biol. 12:277-287(2002) [PubMed] [Europe PMC] [Abstract]