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Defensin Alpha 2 (DEFa2)

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Defcr2; Defensin-Related Cryptdin-2; Cryptdin-1

Defensin Alpha 2 (DEFa2)
CCC S834
MGI 94882
UniProt P28309
DEFa2 belongs to the alpha-defensin family, Has broad-spectrum antimicrobial properties. Has antibacterial activity against the Gram-positive bacterium L.monocytogenes EGD and the Gram-negative bacteria E.coli ML-35p and avirulent S.typhimurium 7953, but not against the mouse-virulent S.typhimurium 14028S.
DEFA1 and DEFA3 differ only by the first amino acid of the mature peptides and DEFA2 lacks this residue. Given that no gene for DEFA2 has been discovered, it is thought that DEFA2 is a proteolytic product of one or both of DEFA1 and DEFA3. DEFA1 and DEFA2 are active against Candida albicans and are chemotactic for T-cells whereas DEFA3 is not. DEFA1 and DEFA2 have recently been observed to be more potent than DEFA3 against the Gram negative bacteria Enterobacter aerogenes and Escherichia coli as well as the Gram positive Staphylococcus aureus and Bacillus cereus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS834Hu01 Recombinant Defensin Alpha 2 (DEFa2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAS834Hu01 Polyclonal Antibody to Defensin Alpha 2 (DEFa2) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits n/a CLIA Kit for Defensin Alpha 2 (DEFa2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Defensin Alpha 2 (DEFa2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Defensin Alpha 2 (DEFa2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Defensin Alpha 2 (DEFa2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Defensin Alpha 2 (DEFa2) Polyclonal Antibody Customized Service Offer
Assay Kits SES834Mu ELISA Kit for Defensin Alpha 2 (DEFa2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Defensin Alpha 2 (DEFa2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Defensin Alpha 2 (DEFa2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Defensin Alpha 2 (DEFa2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Defensin Alpha 2 (DEFa2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Defensin Alpha 2 (DEFa2) ELISA Kit Customized Service Offer
  1. "Structure and diversity of the murine cryptdin gene family."Genomics 19:448-453(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Enteric defensins: antibiotic peptide components of intestinal host defense."J. Cell Biol. 118:929-936(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Cryptdins: antimicrobial defensins of the murine small intestine."Infect. Immun. 60:3556-3565(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Genetic mapping of 40 cDNA clones on the mouse genome by PCR."Mamm. Genome 5:349-355(1994) [PubMed] [Europe PMC] [Abstract]