DENN/MADD Domain Containing Protein 2A (DENND2A)

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FAM31D

DENN/MADD Domain Containing Protein 2A (DENND2A)
DENND2A, Contains 1 dDENN domain.Contains 1 DENN domain.Contains 1 uDENN domain. The DENN domain is an evolutionarily ancient protein module. Mutations in the DENN domain cause developmental defects in plants and human diseases, yet the function of this common module is unknown. The connecdenn/DENND1A DENN domain functions as a guanine nucleotide exchange factor (GEF) for Rab35 to regulate endosomal membrane trafficking. Loss of Rab35 activity causes an enlargement of early endosomes and inhibits MHC class I recycling. Moreover, it prevents early endosomal recruitment of EHD1, a common component of tubules involved in endosomal cargo recycling. Distinct Rab GTPases can recruit a common protein machinery to various sites within the endosomal network to establish cargo-selective recycling pathways.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DENN/MADD Domain Containing Protein 2A (DENND2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DENN/MADD Domain Containing Protein 2A (DENND2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DENN/MADD Domain Containing Protein 2A (DENND2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DENN/MADD Domain Containing Protein 2A (DENND2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for DENN/MADD Domain Containing Protein 2A (DENND2A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DENN/MADD Domain Containing Protein 2A (DENND2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DENN/MADD Domain Containing Protein 2A (DENND2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DENN/MADD Domain Containing Protein 2A (DENND2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DENN/MADD Domain Containing Protein 2A (DENND2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for DENN/MADD Domain Containing Protein 2A (DENND2A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DENN/MADD Domain Containing Protein 2A (DENND2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DENN/MADD Domain Containing Protein 2A (DENND2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DENN/MADD Domain Containing Protein 2A (DENND2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DENN/MADD Domain Containing Protein 2A (DENND2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for DENN/MADD Domain Containing Protein 2A (DENND2A) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."J. Cell Biol. 191:367-381(2010) [PubMed] [Europe PMC] [Abstract]