Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4)

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NPP4; AP3Aase; AP3A hydrolase; Bis(5'-adenosyl)-triphosphatase ENPP4

Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4)
ENPP4, Belongs to the nucleotide pyrophosphatase / phosphodiesterase family. Nucleotide pyrophosphatases / phosphodiesterases (NPPs) generate nucleoside 5'-monophosphates from a variety of nucleotides and their derivatives. Homology searches and alignment-assisted mutagenesis revealed that the catalytic core of NPPs assumes a fold similar to that of a superfamily of phospho-/sulfo-coordinating metalloenzymes comprising alkaline phosphatases, phosphoglycerate mutases, and arysulfatases. Mutation of mouse NPP1 in some of its predicted metal-coordinating residues (D358N or H362Q) or in the catalytic site threonine (T238S) resulted in an enzyme that could still form the nucleotidylated catalytic intermediate but was hampered in the second step of catalysis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (ENPP4) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases."J. Biol. Chem. 276:1361-1368(2001) [PubMed] [Europe PMC] [Abstract]
  6. "NPP4 is a procoagulant enzyme on the surface of vascular endothelium."Blood 120:4432-4440(2012) [PubMed] [Europe PMC] [Abstract]
  7. "The molecular basis of purinergic signal metabolism by ecto-nucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke."J. Biol. Chem. 289:3294-3306(2014) [PubMed] [Europe PMC] [Abstract]