≡

Enhancer Of mRNA Decapping Protein 1 (EDC1)

[Edit]

Enhancer Of mRNA Decapping Protein 1 (EDC1)
CCC S809
PubMed 12554866
UniProt P53080

The yeast EDC1 mRNA, which encodes a protein that enhances decapping, has unique properties and is both protected from deadenylation and undergoes deadenylation-independent decapping. The 3' UTR of the EDC1 mRNA is sufficient for both protection from deadenylation and deadenylation-independent decapping and an extended poly(U) tract within the 3' UTR is required. These observations highlight the diverse forms of decapping regulation and identify a feedback loop that can compensate for decreases in activity of the decapping enzyme. Surprisingly, the decapping of the EDC1 mRNA is slowed by the loss of Not2p, Not4p, and Not5p, which interact with the Ccr4p/Pop2p deadenylase complex. This indicates that the Not proteins can affect decapping, which suggests a possible link between the mRNA deadenylation and decapping machinery.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS809Hu01 Recombinant Enhancer Of mRNA Decapping Protein 1 (EDC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS809Hu21 Monoclonal Antibody to Enhancer Of mRNA Decapping Protein 1 (EDC1) WB; IHC; ICC; IP.
PAS809Hu01 Polyclonal Antibody to Enhancer Of mRNA Decapping Protein 1 (EDC1) WB; IHC; ICC; IP.
Assay Kits SES809Hu ELISA Kit for Enhancer Of mRNA Decapping Protein 1 (EDC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: S. cerevisiae (Yeast)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enhancer Of mRNA Decapping Protein 1 (EDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enhancer Of mRNA Decapping Protein 1 (EDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enhancer Of mRNA Decapping Protein 1 (EDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enhancer Of mRNA Decapping Protein 1 (EDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enhancer Of mRNA Decapping Protein 1 (EDC1) ELISA Kit Customized Service Offer
  1. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The reference genome sequence of Saccharomyces cerevisiae: Then and now."G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
  4. "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae."Genetics 157:27-37(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Global analysis of protein localization in budding yeast."Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Analysis of recombinant yeast decapping enzyme."RNA 9:231-238(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme."RNA 9:239-251(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]