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Fatty Acid Binding Protein 10, Liver (FABP10)

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fabp10a; L-BABP; L-FABP; Fatty acid-binding protein, liver; Liver bile acid-binding protein; Liver-type fatty acid-binding protein

Fatty Acid Binding Protein 10, Liver (FABP10)
CCC S806
PubMed 19843178
UniProt Q9I8L5
The paralogous fabp10 gene encoding basic L-FABP, found to date in only nonmammalian vertebrates, was assigned to zebrafish linkage group 16. RT-PCR amplification of mRNA in adults, and in situ hybridization to whole-mount embryos to fabp1a, fabp1b and fapb10 mRNAs, revealed a distinct and differential pattern of expression for the fabp1a, fabp1b and fabp10 genes in zebrafish, suggesting a division of function for these orthogolous and paralogous gene products following their duplication in the vertebrate genome.
The differential and complementary expression patterns of the zebrafish fabp1a, fapb1b and fabp10 genes imply a hierarchical subfunctionalization that may account for the retention of both the duplicated fabp1a and fabp1b genes, and the fabp10 gene in the zebrafish genome.

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fatty Acid Binding Protein 10, Liver (FABP10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fatty Acid Binding Protein 10, Liver (FABP10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fatty Acid Binding Protein 10, Liver (FABP10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fatty Acid Binding Protein 10, Liver (FABP10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fatty Acid Binding Protein 10, Liver (FABP10) ELISA Kit Customized Service Offer
  1. "cDNA sequence and tissue-specific expression of a basic liver-type fatty acid binding protein in adult zebrafish (Danio rerio)."Biochim. Biophys. Acta 1492:227-232(2000) [PubMed] [Europe PMC] [Abstract]
  2. "435-bp liver regulatory sequence in the liver fatty acid binding protein (L-FABP) gene is sufficient to modulate liver regional expression in transgenic zebrafish."Dev. Dyn. 227:347-356(2003) [PubMed] [Europe PMC] [Abstract]
  3. "In vivo studies of liver-type fatty acid binding protein (L-FABP) gene expression in liver of transgenic zebrafish (Danio rerio)."FEBS Lett. 538:125-133(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Hierarchical subfunctionalization of fabp1a, fabp1b and fabp10 tissue-specific expression may account for retention of these duplicated genes in the zebrafish (Danio rerio) genome."FEBS J. 273:3216-3229(2006) [PubMed] [Europe PMC] [Abstract]
  5. "A single amino acid mutation in zebrafish (Danio rerio) liver bile acid-binding protein can change the stoichiometry of ligand binding."J. Biol. Chem. 282:31008-31018(2007) [PubMed] [Europe PMC] [Abstract]