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Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT)

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ZC3HDC9; ZC3H9; GPATC6; GPATCH6; ZIP; G patch domain-containing protein 6; Zinc finger CCCH domain-containing protein 9; Zinc finger and G patch domain-containing protein

Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT)
CCC S793
HGNC 15948
MGI 2449939
PubMed 21666691
RGD 1310801
UniProt Q8N5A5
Wiki ZGPAT
ZGPAT, Contains 1 C3H1-type zinc finger. Contains 1 G-patch domain. Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. Six new targets of epigenetic inactivation (IRX3, WNT10A, WNT6, RARalpha, BMP7 and ZGPAT). These targets displayed cell line and tumor specific differential methylation when compared with normal brain samples, suggesting they may have utility as biomarkers.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, CCCH-Type With G Patch Domain Protein (ZGPAT) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis."EMBO J. 28:2763-2776(2009) [PubMed] [Europe PMC] [Abstract]
  6. "sZIP, an alternative splice variant of ZIP, antagonizes transcription repression and growth inhibition by ZIP."J. Biol. Chem. 285:14301-14307(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "HIV-1 Vpr Induces the Degradation of ZIP and sZIP, Adaptors of the NuRD Chromatin Remodeling Complex, by Hijacking DCAF1/VprBP."PLoS ONE 8:E77320-E77320(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of the zinc finger of ZGPAT."Submitted (FEB-2013) to the PDB data bank