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Histone Cluster 1, H2af (HIST1H2AF)

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Histone Cluster 1, H2af (HIST1H2AF)
CCC S771
MGI 2448309
UniProt Q8CGP5
HIST1H2AF, Belongs to the histone H2A family. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2af (HIST1H2AF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2af (HIST1H2AF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2af (HIST1H2AF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2af (HIST1H2AF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2af (HIST1H2AF) ELISA Kit Customized Service Offer
  1. "The human and mouse replication-dependent histone genes."Genomics 80:487-498(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation."Dev. Cell 7:663-676(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation."J. Biol. Chem. 279:52812-52815(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells."Nat. Cell Biol. 8:623-630(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification."Cell 146:1016-1028(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification."Nature 505:564-568(2014) [PubMed] [Europe PMC] [Abstract]