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Mediator Complex Subunit 3 (MED3)

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PGD1; HRS1; Poly-Glutamine Domain Protein 1; Hyper-Recombination Suppressor Protein 1; Mediator of RNA polymerase II transcription subunit 3

Mediator Complex Subunit 3 (MED3)
CCC S708
PubMed 10722672
UniProt P40356
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. PGD1/MED3 is also involved in direct repeat recombination.

Organism species: S. cerevisiae (Yeast)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 3 (MED3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 3 (MED3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 3 (MED3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 3 (MED3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 3 (MED3) ELISA Kit Customized Service Offer
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