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SH3 And PX Domain Containing Protein 2A (SH3PXD2A)

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SH3MD1; TKS5; FISH; Five SH3 Domains; SH3 Multiple Domains 1; Adapter protein TKS5; Tyrosine kinase substrate with five SH3 domains

SH3 And PX Domain Containing Protein 2A (SH3PXD2A)
CCC S585
HGNC 23664
MGI 1298393
PubMed 23544093
RGD 1311185
UniProt Q5TCZ1
Wiki SH3PXD2A
A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate.
Several potential Src substrates were identified including Fish, which has five SH3 domains and a recently discovered phox homology (PX) domain. Fish is tyrosine-phosphorylated in Src-transformed fibroblasts (suggesting that it is a target of Src in vivo) and in normal cells following treatment with several growth factors. Treatment of cells with cytochalasin D also resulted in rapid tyrosine phosphorylation of Fish, concomitant with activation of Src. These data suggest that Fish is involved in signalling by tyrosine kinases, and imply a specialized role in the actin cytoskeleton.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 And PX Domain Containing Protein 2A (SH3PXD2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 And PX Domain Containing Protein 2A (SH3PXD2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 And PX Domain Containing Protein 2A (SH3PXD2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 And PX Domain Containing Protein 2A (SH3PXD2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 And PX Domain Containing Protein 2A (SH3PXD2A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 And PX Domain Containing Protein 2A (SH3PXD2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 And PX Domain Containing Protein 2A (SH3PXD2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 And PX Domain Containing Protein 2A (SH3PXD2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 And PX Domain Containing Protein 2A (SH3PXD2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 And PX Domain Containing Protein 2A (SH3PXD2A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 And PX Domain Containing Protein 2A (SH3PXD2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 And PX Domain Containing Protein 2A (SH3PXD2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 And PX Domain Containing Protein 2A (SH3PXD2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 And PX Domain Containing Protein 2A (SH3PXD2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 And PX Domain Containing Protein 2A (SH3PXD2A) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells."J. Biol. Chem. 278:16844-16851(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells."Cancer Cell 7:155-165(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity."Proc. Natl. Acad. Sci. U.S.A. 102:3058-3063(2005) [PubMed] [Europe PMC] [Abstract]
  6. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo."Eur. J. Cell Biol. 87:555-567(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity."Sci. Signal. 2:RA54-RA54(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation."Eur. J. Cell Biol. 90:164-171(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of the SH3 domains from human KIAA0418 protein."Submitted (AUG-2007) to the PDB data bank