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WD Repeat And FYVE Domain Containing Protein 1 (WDFY1)

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FENS-1; WDF1; ZFYVE17; WD40 And FYVE Domain Containing 1; Phosphoinositide-binding protein 1; Zinc finger FYVE domain-containing protein 17

WD Repeat And FYVE Domain Containing Protein 1 (WDFY1)
CCC S512
HGNC 20451
MGI 1916618
PubMed 23388383
UniProt Q8IWB7
FENS-1 and DFCP1 are recently discovered proteins containing one or two FYVE-domains respectively. Exogenously expressed FENS-1 localises to early endosomes: this localisation requires an intact FYVE domain and is sensitive to wortmannin inhibition. The isolated FYVE domain of FENS-1 also localises to endosomes. By contrast, exogenously expressed DFCP1 displays a predominantly Golgi, endoplasmic reticulum (ER) and vesicular distribution with little or no overlap with FENS-1 or other endosomal markers. Overexpression of DFCP1 was found to cause dispersal of the Golgi compartment defined by giantin and gpp130-staining. Disruption of the FYVE domains of DFCP1 causes a shift to more condensed and compact Golgi structures and overexpression of this mutant was found to confer significant protection to the Golgi against brefeldin-induced dispersal.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat And FYVE Domain Containing Protein 1 (WDFY1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat And FYVE Domain Containing Protein 1 (WDFY1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat And FYVE Domain Containing Protein 1 (WDFY1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat And FYVE Domain Containing Protein 1 (WDFY1) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat And FYVE Domain Containing Protein 1 (WDFY1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat And FYVE Domain Containing Protein 1 (WDFY1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat And FYVE Domain Containing Protein 1 (WDFY1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat And FYVE Domain Containing Protein 1 (WDFY1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat And FYVE Domain Containing Protein 1 (WDFY1) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat And FYVE Domain Containing Protein 1 (WDFY1) ELISA Kit Customized Service Offer
  1. "FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments."J. Cell Sci. 114:3991-4000(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Membrane insertion of the FYVE domain is modulated by pH."Proteins 76:852-860(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]