-86465.jpg)
PLAC4 is located on chromosome 21 and its expression is restricted to the placenta.PLAC4 and beta-HCG mRNA levels are not altered in the maternal circulation of pregnancies with trisomy 21.
beta-HCG and PLAC4 mRNAs were detected in all samples, in higher amounts than in plasma, whereas the detection rate for PAPP-A mRNA was below 10%. The levels of beta-HCG mRNA significantly correlated with the circulatory concentrations of the HCG protein. However, neither beta-HCG- nor PLAC4 mRNAs show a significant difference between cases and controls. Maternal blood levels of beta-HCG-, PLAC4- and PAPP-A mRNAs are not useful markers for the screening of pregnancies with trisomy 21 as their concentrations are either not significantly altered (beta-HCG and PLAC4) or too low to be detected (PAPP-A).
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Placenta Specific Protein 4 (PLAC4) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Placenta Specific Protein 4 (PLAC4) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Placenta Specific Protein 4 (PLAC4) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Placenta Specific Protein 4 (PLAC4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Placenta Specific Protein 4 (PLAC4) | ELISA Kit Customized Service Offer |
- "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
- "D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma cells."Genomics 17:256-259(1993) [PubMed] [Europe PMC] [Abstract]