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Mitochondrial Transcription Termination Factor 4 (MTERF4)

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MTERFD2; MTERF Domain Containing Protein 2

Mitochondrial Transcription Termination Factor 4 (MTERF4)
CCC S461
HGNC 28785
MGI 1918355
RGD 1562440
UniProt Q7Z6M4
MTERFD2, Belongs to the mTERF family. mTERF1 (mTERF) and mTERF2 (mTERFD3) are 2 groups present only in vertebrates, whereas mTERF3 (mTERFD1) and mTERF4 (mTERFD2) genes are encountered not only in vertebrates but also in worms and insects. mTERF1 (mTERF) group contains the previously characterized mTERF protein, whereas mTERF2 contains the mouse mTERFD3 gene characterized in this work. The characterization of mTERF family members is just emerging so that few reports about the function of mTERF like proteins are available. mtDBP has also a negative regulatory role in mtDNA synthesis since it inhibits a replicative helicase in Paracentrotus lividus. mTERF homologue in Drosophila melanogaster (DmTTF) binds mtDNA in two noncoding regions and was proposed to stop transcription.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitochondrial Transcription Termination Factor 4 (MTERF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitochondrial Transcription Termination Factor 4 (MTERF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitochondrial Transcription Termination Factor 4 (MTERF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitochondrial Transcription Termination Factor 4 (MTERF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitochondrial Transcription Termination Factor 4 (MTERF4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitochondrial Transcription Termination Factor 4 (MTERF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitochondrial Transcription Termination Factor 4 (MTERF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitochondrial Transcription Termination Factor 4 (MTERF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitochondrial Transcription Termination Factor 4 (MTERF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitochondrial Transcription Termination Factor 4 (MTERF4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitochondrial Transcription Termination Factor 4 (MTERF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitochondrial Transcription Termination Factor 4 (MTERF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitochondrial Transcription Termination Factor 4 (MTERF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitochondrial Transcription Termination Factor 4 (MTERF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitochondrial Transcription Termination Factor 4 (MTERF4) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome."Cell Metab. 13:527-539(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis."Proc. Natl. Acad. Sci. U.S.A. 109:15253-15258(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of the essential MTERF4:NSUN4 protein complex reveals how an MTERF protein collaborates to facilitate rRNA modification."Structure 20:1940-1947(2012) [PubMed] [Europe PMC] [Abstract]