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Caspase Recruitment Domain Family, Member 16 (CARD16)

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COP1; COP; PSEUDO-ICE; CARD Only Protein; Caspase Recruitment Domain Only Protein 1; Pseudo interleukin-1 beta converting enzyme

Caspase Recruitment Domain Family, Member 16 (CARD16)
CCC S382
HGNC 33701
PubMed 11432859
UniProt Q5EG05
Wiki COP1
Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. One of the known molecular mechanisms underlying pro-caspase-1 processing and activation involves binding of the caspase-1 prodomain to a caspase recruitment domain-containing serine/threonine kinase known as RIP2/CARDIAK/RICK. COP has a high degree of sequence identity to the caspase-1 prodomain. COP binds to both RIP2 and the caspase-1 prodomain and inhibits RIP2-induced caspase-1 oligomerization. COP inhibits caspase- 1-induced IL-1beta secretion as well as lipopolysaccharide-induced IL-1beta secretion in transfected cells. COP can regulate IL-1beta secretion, implying that COP may play a role in down-regulating inflammatory responses analogous to the CARD protein ICEBERG.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Caspase Recruitment Domain Family, Member 16 (CARD16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Caspase Recruitment Domain Family, Member 16 (CARD16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Caspase Recruitment Domain Family, Member 16 (CARD16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Caspase Recruitment Domain Family, Member 16 (CARD16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase Recruitment Domain Family, Member 16 (CARD16) ELISA Kit Customized Service Offer
  1. "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins."Cell Death Differ. 8:649-657(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing."J. Biol. Chem. 276:34495-34500(2001) [PubMed] [Europe PMC] [Abstract]
  5. "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis."J. Biol. Chem. 277:13952-13958(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease."J. Neurosci. 25:11645-11654(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death."Biochim. Biophys. Acta 1762:742-754(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]