SEC11 Homolog B (SEC11B)
[Edit]SEC11L2; SPCS4B; Putative signal peptidase complex catalytic subunit SEC11B
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Sec11b is one of two signal peptidases (SPases) in the haloarchaeon Haloferax volcanii. Site-directed mutagenesis revealed Ser-72, His-137 and Asp-187 as essential for signal peptide cleavage. Thus, like the SPase of the methanoarchaeon Methanococcus voltae, H. volcanii Sec11b uses a catalytic mechanism reminiscent of its eukaryal rather than its bacterial counterpart. The availability of an additional model system to study the archaeal SPase, now in the form of the purified protein, promises additional insight into the behavior of this enzyme. Sec11b, but not Sec11a, is essential. For purification purposes, tagged versions of the protein products of both genes were expressed in transformed Haloferax volcanii, with Sec11a and Sec11b being fused to a cellulose-binding domain capable of interaction with cellulose in hypersaline surroundings.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant SEC11 Homolog B (SEC11B) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to SEC11 Homolog B (SEC11B) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to SEC11 Homolog B (SEC11B) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for SEC11 Homolog B (SEC11B) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for SEC11 Homolog B (SEC11B) | ELISA Kit Customized Service Offer |
- "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]