Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2)

[Edit]

DOC-1R; p14; Tumor Suppressor Deleted In Oral Cancer Related 1

Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2)
The tumor suppressor gene MEN1 and several oncogenes including CCND1/cyclin D1/PRAD1 map to chromosome 11q13. However, molecular and cytogenetic analysis suggests the presence of a second tumor suppressor locus at this chromosome region. DOC-1R, a DOC-1 growth suppressor-related gene. The cytogenetic location was confirmed by chromosome fluorescent in situ hybridization. Northern blot analysis indicated that it was expressed in all the tissues examined. DOC-1R protein showed heterogeneous subcellular localization. RT-PCR-SSCP analysis failed to detect deleterious mutations of the DOC-1R transcript in four premalignant oral keratinocyte lines and 20 different cancer cell lines from tumor types which frequently harbor LOH at chromosome 11q13.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 2 Associated Protein 2 (CDK2AP2) ELISA Kit Customized Service Offer
  1. "Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene."Biochem. Biophys. Res. Commun. 255:59-63(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]