YTH Domain Containing Protein 1 (YTHDC1)

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YT521-B; Putative splicing factor YT521

YTH Domain Containing Protein 1 (YTHDC1)
YT521-B protein is localized in the nucleoplasm and concentrated in 5-20 large nuclear dots. Deletion analysis demonstrated that the formation of these dots depends on the presence of the amino-terminal glutamic acid-rich domain and the carboxyl-terminal glutamic acid/arginine-rich region.
The Src family kinase p59(fyn)-mediated tyrosine phosphorylation of Sam68 negatively regulates its association with YT521-B, and overexpression of p59(fyn) dissolves nuclear dots containing YT521-B. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner. YT521-B and Sam68 may be part of a signal transduction pathway that influences splice site selection.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant YTH Domain Containing Protein 1 (YTHDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to YTH Domain Containing Protein 1 (YTHDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to YTH Domain Containing Protein 1 (YTHDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for YTH Domain Containing Protein 1 (YTHDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for YTH Domain Containing Protein 1 (YTHDC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant YTH Domain Containing Protein 1 (YTHDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to YTH Domain Containing Protein 1 (YTHDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to YTH Domain Containing Protein 1 (YTHDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for YTH Domain Containing Protein 1 (YTHDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for YTH Domain Containing Protein 1 (YTHDC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant YTH Domain Containing Protein 1 (YTHDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to YTH Domain Containing Protein 1 (YTHDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to YTH Domain Containing Protein 1 (YTHDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for YTH Domain Containing Protein 1 (YTHDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for YTH Domain Containing Protein 1 (YTHDC1) ELISA Kit Customized Service Offer
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  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "The YTH domain is a novel RNA binding domain."J. Biol. Chem. 285:14701-14710(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain."Nat. Chem. Biol. 10:927-929(2014) [PubMed] [Europe PMC] [Abstract]