Dermal Papilla Derived Protein 6 (DERP6)

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ELP5; C17orf81; S-Phase 2 Protein; Elongator complex protein 5

Dermal Papilla Derived Protein 6 (DERP6)
DERP6 is a 316 amino acid protein that localizes to the cytoplasm and exists as multiple alternatively spliced isoforms. Expressed ubiquitously with highest expression in liver, heart, testis, brain and skeletal muscle, DERP6 is thought to be involved in p53-mediated transcriptional regulation. The DERP6 cDNA consists of 1486 nucleotides and has a 316-amino acids open reading frame. The Northern hybridization analysis showed that DERP6 was ubiquitously expressed in all the 16 adult tissues, especially highly expressed in heart, brain, liver, skeletal muscle and testis. DERP6 protein was located in cytoplasm when overexpressed in cultured cells. Reporter gene assays showed that overexpression of DERP6 in cells activated the transcriptional activities of p53. These results indicate that the human gene DERP6 may be involved in p53-mediated gene transcription.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dermal Papilla Derived Protein 6 (DERP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dermal Papilla Derived Protein 6 (DERP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dermal Papilla Derived Protein 6 (DERP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dermal Papilla Derived Protein 6 (DERP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dermal Papilla Derived Protein 6 (DERP6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dermal Papilla Derived Protein 6 (DERP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dermal Papilla Derived Protein 6 (DERP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dermal Papilla Derived Protein 6 (DERP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dermal Papilla Derived Protein 6 (DERP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dermal Papilla Derived Protein 6 (DERP6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dermal Papilla Derived Protein 6 (DERP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dermal Papilla Derived Protein 6 (DERP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dermal Papilla Derived Protein 6 (DERP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dermal Papilla Derived Protein 6 (DERP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dermal Papilla Derived Protein 6 (DERP6) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53."Mol. Biol. Rep. 33:151-158(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator."J. Biol. Chem. 287:32535-32545(2012) [PubMed] [Europe PMC] [Abstract]