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SR Related CTD Associated Factor 1 (SCAF1)

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SFRS19; SRA1; Serine arginine-rich pre-mRNA splicing factor SR-A1; Splicing factor, arginine/serine-rich 19

SR Related CTD Associated Factor 1 (SCAF1)
CCC S150
HGNC 30403
MGI 2141980
PubMed 24131527
RGD 708405
UniProt Q9H7N4
The SR-A1 protein is composed of 1312 amino acids, with a molecular mass of 139.3 kDa and a theoretical isoelectric point of 9.31. The SR-A1 protein contains an SR-rich domain as well as a CTD-binding domain present only in a subset of SR-proteins. Through interactions with the pre-mRNA and the CTD domain of the Polymerase II, SR proteins have been shown to regulate alternative splicing. The SR-A1 gene is expressed in all tissues tested, with highest levels found in fetal brain and fetal liver. SR-A1 is overexpressed in a subset of ovarian cancers which are clinically more aggressive.SR-A1 is constitutively expressed. Furthermore, the mRNA of the SR-A1 gene in these cell lines appears to increase by estrogens, androgens and glucocorticoids, and to a lesser extend by progestins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SR Related CTD Associated Factor 1 (SCAF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SR Related CTD Associated Factor 1 (SCAF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SR Related CTD Associated Factor 1 (SCAF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SR Related CTD Associated Factor 1 (SCAF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SR Related CTD Associated Factor 1 (SCAF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SR Related CTD Associated Factor 1 (SCAF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SR Related CTD Associated Factor 1 (SCAF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SR Related CTD Associated Factor 1 (SCAF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SR Related CTD Associated Factor 1 (SCAF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SR Related CTD Associated Factor 1 (SCAF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SR Related CTD Associated Factor 1 (SCAF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SR Related CTD Associated Factor 1 (SCAF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SR Related CTD Associated Factor 1 (SCAF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SR Related CTD Associated Factor 1 (SCAF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SR Related CTD Associated Factor 1 (SCAF1) ELISA Kit Customized Service Offer
  1. "Cloning of a gene (SR-A1), encoding for a new member of the human Ser/Arg-rich family of pre-mRNA splicing factors: overexpression in aggressive ovarian cancer."Br. J. Cancer 85:190-198(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "SR-A1, a member of the human pre-mRNA splicing factor family, and its expression in colon cancer progression."Biol. Chem. 385:785-790(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of the C-terminal domain of novel human SR-A1 protein: interaction with the CTD domain of RNA polymerase II."Biochem. Biophys. Res. Commun. 334:61-68(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Expression analysis and prognostic significance of the SRA1 gene, in ovarian cancer."Biochem. Biophys. Res. Commun. 344:667-674(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Prognostic significance of the expression of SR-A1, encoding a novel SR-related CTD-associated factor, in breast cancer."Biol. Chem. 387:1613-1618(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]