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Nin One Binding Protein (NOB1)

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PSMD8BP1; NOB1P; ART-4; PSMD8 Binding Protein 1; NIN1/RPN12 Binding Protein 1; Phosphorylation regulatory protein HP-10; RNA-binding protein NOB1

Nin One Binding Protein (NOB1)
CCC S013
HGNC 29540
MGI 1914869
PubMed 19706509
RGD 735222
UniProt Q9ULX3
Wiki NOB1
Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA. The deduced 412-amino acid human protein shares significant homology with yeast Nob1 and its eukaryotic orthologs, including a highly conserved PIN domain, which is predicted to be involved in RNA degradation, and complete conservation of 4 cysteines in the metal-binding zinc ribbon domain. Immunofluorescence microscopy of yeast detected Nob1 in both the nucleus and cytoplasm. Nob1 associated with pre-40S ribosomal particles. Conditional Nob1 knockout in yeast led to accumulation of the 20S rRNA intermediate and a block in processing of the 20S pre-rRNA to the mature 18S rRNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nin One Binding Protein (NOB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nin One Binding Protein (NOB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nin One Binding Protein (NOB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nin One Binding Protein (NOB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nin One Binding Protein (NOB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nin One Binding Protein (NOB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nin One Binding Protein (NOB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nin One Binding Protein (NOB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nin One Binding Protein (NOB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nin One Binding Protein (NOB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nin One Binding Protein (NOB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nin One Binding Protein (NOB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nin One Binding Protein (NOB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nin One Binding Protein (NOB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nin One Binding Protein (NOB1) ELISA Kit Customized Service Offer
  1. "Cloning, expression and characterization of the human NOB1 gene."Mol. Biol. Rep. 32:185-189(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. , Submitted (JUL-2007) to UniProtKB
  5. "Cloning and expression of a new human polypeptide which regulates protein phosphorylation in Escherichia coli."Mol. Cell. Biochem. 107:87-94(1991) [PubMed] [Europe PMC] [Abstract]
  6. "A protein interaction framework for human mRNA degradation."Genome Res. 14:1315-1323(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]