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Cross GTPase Activating Protein (CrGAP)

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ARHGAP39; Vilse; crossGAP; Rho GTPase Activating Protein 39

Cross GTPase Activating Protein (CrGAP)
CCC R991
HGNC 29351
MGI 107858
PubMed 15755809
RGD 1593158
UniProt Q9C0H5
The regulators of the Rho-family GTPases, GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs), play important roles in axon guidance.
CrossGAP (CrGAP), which is involved in Roundabout (Robo) receptor-mediated repulsive axon guidance. CrGAP physically associates with the Robo receptor. Too much or too little CrGAP activity leads to defects in Robo-mediated repulsion at the midline choice point. The CrGAP gain-of-function phenotype mimics the loss-of-function phenotypes of both Robo and Rac. Dosage-sensitive genetic interactions among CrGAP, Robo, and Rac support a model in which CrGAP transduces signals downstream of Robo receptor to regulate Rac-dependent cytoskeletal changes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cross GTPase Activating Protein (CrGAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cross GTPase Activating Protein (CrGAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cross GTPase Activating Protein (CrGAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cross GTPase Activating Protein (CrGAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cross GTPase Activating Protein (CrGAP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cross GTPase Activating Protein (CrGAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cross GTPase Activating Protein (CrGAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cross GTPase Activating Protein (CrGAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cross GTPase Activating Protein (CrGAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cross GTPase Activating Protein (CrGAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cross GTPase Activating Protein (CrGAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cross GTPase Activating Protein (CrGAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cross GTPase Activating Protein (CrGAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cross GTPase Activating Protein (CrGAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cross GTPase Activating Protein (CrGAP) ELISA Kit Customized Service Offer
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  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]