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Functional Spliceosome Associated Protein b (fSAPb)

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CWC22; EIF4GL; NCM; Nucampholin homolog

Functional Spliceosome Associated Protein b (fSAPb)
CCC R985
HGNC 29322
MGI 2136773
PubMed 18278176
RGD 1565385
UniProt Q9HCG8
Cwc22 was previously identified to associate with the pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex involved in spliceosome activation. Cwc22 is required for pre-mRNA splicing both in vivo and in vitro but is neither tightly associated with the NTC nor required for spliceosome activation. Cwc22 is associated with the spliceosome prior to catalytic steps and remains associated throughout the reaction.
Although Cwc22 is not required for the recruitment of Prp2 to the spliceosome, it is essential for the function of Prp2 in promoting the release of the U2 components SF3a and SF3b. Cwc22 represents a novel ATP-dependent step one factor besides Prp2 and Spp2 and has a distinct role from that of Spp2 in mediating the function of Prp2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Functional Spliceosome Associated Protein b (fSAPb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Functional Spliceosome Associated Protein b (fSAPb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Functional Spliceosome Associated Protein b (fSAPb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Functional Spliceosome Associated Protein b (fSAPb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Functional Spliceosome Associated Protein b (fSAPb) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Functional Spliceosome Associated Protein b (fSAPb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Functional Spliceosome Associated Protein b (fSAPb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Functional Spliceosome Associated Protein b (fSAPb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Functional Spliceosome Associated Protein b (fSAPb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Functional Spliceosome Associated Protein b (fSAPb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Functional Spliceosome Associated Protein b (fSAPb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Functional Spliceosome Associated Protein b (fSAPb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Functional Spliceosome Associated Protein b (fSAPb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Functional Spliceosome Associated Protein b (fSAPb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Functional Spliceosome Associated Protein b (fSAPb) ELISA Kit Customized Service Offer
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