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Kelch Like Protein 42 (KLHL42)

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Ctb9; KLHDC5; Kelch Domain Containing Protein 5; Cullin-3-binding protein 9

Kelch Like Protein 42 (KLHL42)
CCC R973
HGNC 29252
MGI 2444786
PubMed 19261606
RGD 1560924
UniProt Q9P2K6
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. E3 ubiquitin ligases are involved in targeting specific substrates for degradation by facilitating their ubiquitination.
Overexpression of Ctb9/KLHDC5 resulted in an increase in microtubule density as well as persistent microtubule bridges between post-mitotic cells. Conversely, down-regulation of Ctb9/KLHDC5 showed a pronounced reduction in microtubule density. p60/katanin interacts with a complex consisting of Cul3 and Ctb9/KLHDC5, which results in ubiquitin laddering of p60/katanin. Also, Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5 is required for efficient p60/katanin removal.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kelch Like Protein 42 (KLHL42) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kelch Like Protein 42 (KLHL42) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kelch Like Protein 42 (KLHL42) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kelch Like Protein 42 (KLHL42) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kelch Like Protein 42 (KLHL42) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kelch Like Protein 42 (KLHL42) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kelch Like Protein 42 (KLHL42) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kelch Like Protein 42 (KLHL42) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kelch Like Protein 42 (KLHL42) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kelch Like Protein 42 (KLHL42) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kelch Like Protein 42 (KLHL42) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kelch Like Protein 42 (KLHL42) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kelch Like Protein 42 (KLHL42) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kelch Like Protein 42 (KLHL42) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kelch Like Protein 42 (KLHL42) ELISA Kit Customized Service Offer
  1. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  4. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells."J. Biol. Chem. 284:11663-11675(2009) [PubMed] [Europe PMC] [Abstract]