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GDP Mannose Pyrophosphorylase B (GMPPB)

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Mannose-1-Phosphate Guanyltransferase Beta

GDP Mannose Pyrophosphorylase B (GMPPB)
CCC R941
HGNC 22932
MGI 2660880
PubMed 23768512
RGD 1560458
UniProt Q9Y5P6
Wiki GMPPB
GMPPB is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. GDP-mannose pyrophosphorylase (GMPP) catalyses the synthesis of GDP-mannose, which is the precursor for the mannose residues in glycoconjugates, using mannose 1-phosphate and GTP as substrates. Repression of GMPP in yeast leads to phenotypes including cell lysis, defective cell wall, and failure of polarized growth and cell separation. A prerequisite for the synthesis of these molecules is the availability of the activated mannose donor, GDP-Man, the product of the catalysis of mannose-1-phosphate and GTP by GDP-mannose pyrophosphorylase (GDP-MP).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GDP Mannose Pyrophosphorylase B (GMPPB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GDP Mannose Pyrophosphorylase B (GMPPB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GDP Mannose Pyrophosphorylase B (GMPPB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GDP Mannose Pyrophosphorylase B (GMPPB) CLIA Kit Customized Service Offer
n/a ELISA Kit for GDP Mannose Pyrophosphorylase B (GMPPB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GDP Mannose Pyrophosphorylase B (GMPPB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GDP Mannose Pyrophosphorylase B (GMPPB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GDP Mannose Pyrophosphorylase B (GMPPB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GDP Mannose Pyrophosphorylase B (GMPPB) CLIA Kit Customized Service Offer
n/a ELISA Kit for GDP Mannose Pyrophosphorylase B (GMPPB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GDP Mannose Pyrophosphorylase B (GMPPB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GDP Mannose Pyrophosphorylase B (GMPPB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GDP Mannose Pyrophosphorylase B (GMPPB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GDP Mannose Pyrophosphorylase B (GMPPB) CLIA Kit Customized Service Offer
n/a ELISA Kit for GDP Mannose Pyrophosphorylase B (GMPPB) ELISA Kit Customized Service Offer
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  6. "Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of alpha-dystroglycan." Am. J. Hum. Genet. 93:29-41(2013) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]