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Death Inducing Protein (DIP)

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GRAMD4; GRAM Domain Containing 4

Death Inducing Protein (DIP)
CCC R937
HGNC 29113
MGI 2676308
PubMed 19075582
RGD 1309983
UniProt Q6IC98
Overexpression studies of KIAA0767, termed D(eath)-I(nducing)-P(rotein), revealed its strong proapoptotic effect. DIP greatly reduced cell viability in several in vitro systems accompanied by typical apoptotic features such as caspase-3 activation and cleavage of poly(ADP-ribose)-polymerase. Endogenous DIP levels increased following E2F1 activation. Yet, inhibition of endogenous DIP function by small interfering RNA rescued p53-negative cells from E2F1-induced apoptosis, indicating that DIP is an essential mediator of the p53-independent E2F1 death pathway. Localization studies showed that DIP localizes to the mitochondria, where endogenous DIP is upregulated following E2F1 induction. These results provide new insights to the incompletely understood regulatory mechanisms of E2F1-induced apoptosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Death Inducing Protein (DIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Death Inducing Protein (DIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Death Inducing Protein (DIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Death Inducing Protein (DIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Death Inducing Protein (DIP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Death Inducing Protein (DIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Death Inducing Protein (DIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Death Inducing Protein (DIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Death Inducing Protein (DIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Death Inducing Protein (DIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Death Inducing Protein (DIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Death Inducing Protein (DIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Death Inducing Protein (DIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Death Inducing Protein (DIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Death Inducing Protein (DIP) ELISA Kit Customized Service Offer
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  6. "A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53."Cell Death Differ. 12:347-357(2005) [PubMed] [Europe PMC] [Abstract]
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