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ECM29 Homolog (ECM29)

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Proteasome-associated protein ECM29 homolog

ECM29 Homolog (ECM29)
CCC R922
HGNC 29020
MGI 2140220
PubMed 23995839
RGD 1306148
UniProt Q5VYK3
Ecm29p, a 200-kDa yeast protein that contains numerous HEAT repeats as well as a putative VHS domain. The antibodies show that Ecm29 is present exclusively on 26 S proteasomes in HeLa cells and that Ecm29 levels vary markedly among mouse organs.
Confocal immunofluorescence microscopy localizes Ecm29 to the centrosome and a subset of secretory compartments including endosomes, the ER and the ERGIC. Ecm29 is up-regulated 2-3-fold in toxinresistant mutant CHO cells exhibiting increased rates of ER-associated degradation.Ecm29 serves to couple the 26 S proteasome to secretory compartments engaged in quality control and to other sites of enhanced proteolysis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ECM29 Homolog (ECM29) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ECM29 Homolog (ECM29) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ECM29 Homolog (ECM29) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ECM29 Homolog (ECM29) CLIA Kit Customized Service Offer
n/a ELISA Kit for ECM29 Homolog (ECM29) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ECM29 Homolog (ECM29) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ECM29 Homolog (ECM29) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ECM29 Homolog (ECM29) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ECM29 Homolog (ECM29) CLIA Kit Customized Service Offer
n/a ELISA Kit for ECM29 Homolog (ECM29) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ECM29 Homolog (ECM29) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ECM29 Homolog (ECM29) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ECM29 Homolog (ECM29) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ECM29 Homolog (ECM29) CLIA Kit Customized Service Offer
n/a ELISA Kit for ECM29 Homolog (ECM29) ELISA Kit Customized Service Offer
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  5. "Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles."J. Biol. Chem. 279:54849-54861(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components."J. Biol. Chem. 285:31616-31633(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
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  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]