≡

La Ribonucleoprotein Domain Family, Member 5 (LARP5)

[Edit]

LARP4B; La Related Protein 4B

La Ribonucleoprotein Domain Family, Member 5 (LARP5)
CCC R915
HGNC 28987
MGI 106330
RGD 1310713
UniProt Q92615
LARP4B, a thus far uncharacterized member of the LARP family. LARP4B is a cytosolic protein that accumulates upon arsenite treatment in cellular stress granules. Biochemical experiments further uncovered an interaction of LARP4B with the cytosolic poly(A) binding protein 1 (PABPC1) and the receptor for activated C Kinase (RACK1), a component of the 40S ribosomal subunit. Under physiological conditions, LARP4B co-sedimented with polysomes in cellular extracts, suggesting a role in translation. In agreement with this notion, overexpression of LARP4B stimulated protein synthesis, whereas knockdown of the factor by RNA interference impaired translation of a large number of cellular mRNAs. LARP4B as a stimulatory factor of translation. LARP4B exerts its function by bridging mRNA factors of the 3′ end with initiating ribosomes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant La Ribonucleoprotein Domain Family, Member 5 (LARP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to La Ribonucleoprotein Domain Family, Member 5 (LARP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to La Ribonucleoprotein Domain Family, Member 5 (LARP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for La Ribonucleoprotein Domain Family, Member 5 (LARP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for La Ribonucleoprotein Domain Family, Member 5 (LARP5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant La Ribonucleoprotein Domain Family, Member 5 (LARP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to La Ribonucleoprotein Domain Family, Member 5 (LARP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to La Ribonucleoprotein Domain Family, Member 5 (LARP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for La Ribonucleoprotein Domain Family, Member 5 (LARP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for La Ribonucleoprotein Domain Family, Member 5 (LARP5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant La Ribonucleoprotein Domain Family, Member 5 (LARP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to La Ribonucleoprotein Domain Family, Member 5 (LARP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to La Ribonucleoprotein Domain Family, Member 5 (LARP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for La Ribonucleoprotein Domain Family, Member 5 (LARP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for La Ribonucleoprotein Domain Family, Member 5 (LARP5) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  15. "A stimulatory role for the La-related protein 4B in translation."RNA 16:1488-1499(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]