Cation Transport Regulator Like Protein 1 (CHAC1)
[Edit]BOTCH; Gamma-GCG 1; Glutathione-specific gamma-glutamylcyclotransferase 1; Blocks Notch protein
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CHAC1/MGC4504 Is a Novel Proapoptotic Component of the Unfolded Protein Response, Downstream of the ATF4-ATF3-CHOP Cascade
CHAC1 (cation transport regulator-like protein 1), a novel gene regulated by ox-PAPC (oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine), was identified in a co-regulated group of genes enriched for components of the ATF4 (activating transcription factor 4) arm of the unfolded protein response pathway. CHAC1 overexpression enhanced apoptosis, while CHAC1 small interfering RNA suppressed apoptosis, as determined by TUNEL, PARP (poly(ADP-ribose) polymerase) cleavage, and AIF (apoptosis-inducing factor) nuclear translocation.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cation Transport Regulator Like Protein 1 (CHAC1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cation Transport Regulator Like Protein 1 (CHAC1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cation Transport Regulator Like Protein 1 (CHAC1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cation Transport Regulator Like Protein 1 (CHAC1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cation Transport Regulator Like Protein 1 (CHAC1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cation Transport Regulator Like Protein 1 (CHAC1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cation Transport Regulator Like Protein 1 (CHAC1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cation Transport Regulator Like Protein 1 (CHAC1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cation Transport Regulator Like Protein 1 (CHAC1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cation Transport Regulator Like Protein 1 (CHAC1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cation Transport Regulator Like Protein 1 (CHAC1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cation Transport Regulator Like Protein 1 (CHAC1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cation Transport Regulator Like Protein 1 (CHAC1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cation Transport Regulator Like Protein 1 (CHAC1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cation Transport Regulator Like Protein 1 (CHAC1) | ELISA Kit Customized Service Offer |
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- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade."J. Immunol. 182:466-476(2009) [PubMed] [Europe PMC] [Abstract]
- "Botch promotes neurogenesis by antagonizing Notch."Dev. Cell 22:707-720(2012) [PubMed] [Europe PMC] [Abstract]
- "Mammalian proapoptotic factor ChaC1 and its homologues function as gamma-glutamyl cyclotransferases acting specifically on glutathione."EMBO Rep. 13:1095-1101(2012) [PubMed] [Europe PMC] [Abstract]