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DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2)

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FAM6A; Family With Sequence Similarity 6, Member A

DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2)
CCC R863
HGNC 28648
MGI 2442555
PubMed 23594738
RGD 1560168
UniProt Q8IYB7
The exosome is a multisubunit complex composed of several highly conserved subunits, some of which are 3' to 5' exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3' region.
DIS3L2 (DIS3-like exonuclease 2) is an 885 amino acid protein that is thought to function as an exonuclease and may be required for the 3' processing of pre-mRNA into mature mRNA. Defects or chromosomal translocations involving the gene encoding DIS3L2 may be associated with Marfanoid habitus, a genetic disorder characterized by abnormalities in the skeleton, eyes and cardiovascular system. DIS3L2 is expressed as five isoforms due to alternative splicing events.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for DIS3 Mitotic Control Homolog Like Protein 2 (DIS3L2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
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  6. "Overexpression of the C-type natriuretic peptide (CNP) is associated with overgrowth and bone anomalies in an individual with balanced t(2;7) translocation."Hum. Mutat. 28:724-731(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility." Nat. Genet. 44:277-284(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Perlman Syndrome: Overgrowth, Wilms Tumor Predisposition and DIS3L2."Am. J. Med. Genet. C. Semin. Med. Genet. 0:0-0(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA."EMBO J. 32:1855-1868(2013) [PubMed] [Europe PMC] [Abstract]
  13. "Homozygous deletion of DIS3L2 exon 9 due to non-allelic homologous recombination between LINE-1s in a Japanese patient with Perlman syndrome."Eur. J. Hum. Genet. 21:1316-1319(2013) [PubMed] [Europe PMC] [Abstract]
  14. "Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs."RNA 19:1632-1638(2013) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]