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NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6)

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C8orf38; Putative phytoene synthase

NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6)
CCC R857
HGNC 28625
MGI 1924197
PubMed 22019594
RGD 1309085
UniProt Q330K2
C8orf38 is a putative phytoene synthase that is important for the function of complex I (CI) of the electron transport chain. The encoded protein localizes to mitochondria. Defects in this gene are a cause of complex I mitochondrial respiratory chain deficiency.
The deduced protein is highly conserved in eukaryotes, and its domain structure suggests that it is involved in phytoene metabolism, implicating it in branched-chain lipid metabolism.Knockdown of C8ORF38 in human fibroblasts via RNA interference reduced the abundance and activity of mitochondrial complex I to levels comparable to those seen with knockdown of NDUFAF1, a complex I assembly factor. C8ORF38 is essential for activity and/or assembly of complex I.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 6 (NDUFaF6) ELISA Kit Customized Service Offer
  1. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A mitochondrial protein compendium elucidates complex I disease biology."Cell 134:112-123(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations in the gene encoding C8orf38 block complex I assembly by inhibiting production of the mitochondria-encoded subunit ND1."J. Mol. Biol. 414:413-426(2011) [PubMed] [Europe PMC] [Abstract]