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Solute Carrier Family 35, Member G2 (SLC35G2)

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TMEM22; Transmembrane Protein 22

Solute Carrier Family 35, Member G2 (SLC35G2)
CCC R835
HGNC 28480
MGI 2685365
PubMed 11230166
RGD 1306109
UniProt Q8TBE7
Wiki TMEM22
TMEM22 (transmembrane protein 22), a transmembrane protein, in cell growth of RCC. Northern blot and semi-quantitative RT-PCR analyses confirmed up-regulation of TMEM22 in a great majority of RCC clinical samples and cell lines examined. Immunocytochemical analysis validated its localization at the plasma membrane. An interaction between TMEM22 and RAB37 (Ras-related protein Rab-37), which was also up-regulated in RCC cells. Interestingly, knockdown of either of TMEM22 or RAB37 expression by specific siRNA caused significant reduction of cancer cell growth.
TMEM22/RAB37 complex is likely to play a crucial role in growth of RCC and that inhibition of the TMEM22/RAB37 expression or their interaction should be novel therapeutic targets for RCC.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 35, Member G2 (SLC35G2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 35, Member G2 (SLC35G2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 35, Member G2 (SLC35G2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 35, Member G2 (SLC35G2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 35, Member G2 (SLC35G2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 35, Member G2 (SLC35G2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 35, Member G2 (SLC35G2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 35, Member G2 (SLC35G2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 35, Member G2 (SLC35G2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 35, Member G2 (SLC35G2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 35, Member G2 (SLC35G2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 35, Member G2 (SLC35G2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 35, Member G2 (SLC35G2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 35, Member G2 (SLC35G2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 35, Member G2 (SLC35G2) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
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  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells."Oncol. Rep. 21:305-312(2009) [PubMed] [Europe PMC] [Abstract]