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Sorting Nexin 33 (SNX33)

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SH3PX3; SH3PXD3C; SNX30; SH3 And PX Domain Containing 3

Sorting Nexin 33 (SNX33)
CCC R829
HGNC 28468
MGI 2443239
PubMed 22718350
RGD 1307898
UniProt Q8WV41
SNX33, as a new activator of APP alpha-secretase cleavage. SNX33 is a homolog of SNX9 and was found to be a ubiquitously expressed phosphoprotein. Exogenous expression of SNX33 in cultured cells increased APP alpha-secretase cleavage 4-fold but surprisingly had little effect on beta-secretase cleavage. This effect was similar to the expression of the dominant negative dynamin-1 mutant K44A. SNX33 bound the endocytic GTPase dynamin and reduced the rate of APP endocytosis in a dynamin-dependent manner. This led to an increase of APP at the plasma membrane, where alpha-secretase cleavage mostly occurs. SNX33 as a new endocytic protein, which modulates APP endocytosis and APP alpha-secretase cleavage, and demonstrates that the rate of APP endocytosis is a major control factor for APP alpha-secretase cleavage.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 33 (SNX33) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 33 (SNX33) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 33 (SNX33) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 33 (SNX33) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 33 (SNX33) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 33 (SNX33) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 33 (SNX33) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 33 (SNX33) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 33 (SNX33) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 33 (SNX33) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 33 (SNX33) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 33 (SNX33) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 33 (SNX33) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 33 (SNX33) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 33 (SNX33) ELISA Kit Customized Service Offer
  1. "Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome."EMBO Rep. 7:186-191(2006) [PubMed] [Europe PMC] [Abstract]
  2. "A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein."J. Biol. Chem. 283:14257-14268(2008) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding."Traffic 9:1116-1129(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein."J. Biol. Chem. 284:21659-21669(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins."J. Cell. Biochem. 108:877-885(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins."PLoS ONE 5:E13763-E13763(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33."Biochem. J. 433:75-83(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis."J. Cell Sci. 125:4372-4382(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Structure of human sorting nexin 33."Submitted (DEC-2012) to the PDB data bank