Spindle And Kinetochore Associated Complex Subunit 2 (SKA2)

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FAM33A

Spindle And Kinetochore Associated Complex Subunit 2 (SKA2)
SKA2 was found in the cytoplasm, where it co-localized with GR, but nuclear expression of SKA2 was seen in breast tumours. SKA2 overexpression increased GC transactivation in HepG2 cells while SKA2 knockdown in A549 human lung epithelial cells decreased transactivation and prevented dexamethasone inhibition of proliferation. GC treatment decreased SKA2 protein levels in A549 cells, as did Staurosporine, phorbol ester and trichostatin A; all agents that inhibit cell proliferation. Overexpression of SKA2 potentiated the proliferative response to IGF-I exposure, and knockdown with shRNA caused cells to arrest in mitosis. SKA2 has recently been identified in HeLa S3 cells as part of a complex, which is critical for spindle checkpoint silencing and exit from mitosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spindle And Kinetochore Associated Complex Subunit 2 (SKA2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2."EMBO J. 25:5504-5515(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor."J. Endocrinol. 198:499-509(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility."Dev. Cell 16:374-385(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]