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Zinc Finger Protein 473 (ZNF473)

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HZFP100; ZN473; Zinc finger protein 100 homolog

Zinc Finger Protein 473 (ZNF473)
CCC R704
HGNC 23239
MGI 2442697
PubMed 11782445
RGD 1305084
UniProt Q8WTR7
Wiki ZNF473
The stem-loop binding protein (SLBP) is the posttranscriptional regulator of histone mRNA in metazoan cells. SLBP binds histone pre-mRNAs and facilitates 3'-end processing by promoting stable association of U7 snRNP with the pre-mRNA.
A novel zinc finger protein, hZFP100, which interacts with the SLBP/RNA complex but not with free SLBP, was cloned. The interaction requires regions of SLBP that are important for histone pre-mRNA processing. Antibodies to hZFP100 precipitate U7 snRNA, and expression of hZFP100 in Xenopus oocytes stimulates processing of histone pre-mRNA, showing that hZFP100 is a component of the processing machinery.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Protein 473 (ZNF473) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein 473 (ZNF473) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein 473 (ZNF473) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein 473 (ZNF473) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein 473 (ZNF473) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Protein 473 (ZNF473) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein 473 (ZNF473) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein 473 (ZNF473) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein 473 (ZNF473) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein 473 (ZNF473) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Protein 473 (ZNF473) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein 473 (ZNF473) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein 473 (ZNF473) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein 473 (ZNF473) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein 473 (ZNF473) ELISA Kit Customized Service Offer
  1. "A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing."Genes Dev. 16:58-71(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing."Genes Dev. 17:2321-2333(2003) [PubMed] [Europe PMC] [Abstract]
  7. "U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA 3'-end processing."Nucleic Acids Res. 33:2106-2117(2005) [PubMed] [Europe PMC] [Abstract]
  8. "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase."Mol. Cell. Biol. 26:6702-6712(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein."RNA 12:1206-1218(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the C2H2 type zinc finger region of human zinc finger protein 473."Submitted (OCT-2007) to the PDB data bank