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Protein Associated With Topoisomerase II Homolog 1 (PATL1)

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PAT1-like protein 1

Protein Associated With Topoisomerase II Homolog 1 (PATL1)
CCC R660
HGNC 26721
MGI 2147679
PubMed 17936923
RGD 1305514
UniProt Q86TB9
PATL1, codes for an ORF with similar features as the yeast PAT1. As expected for a protein with a fundamental role in translation control, PATL1 mRNA was ubiquitously expressed in all human tissues as were the mRNAs of LSM1 and RCK, the human homologs of yeast LSM1 and DHH1, respectively. Furthermore, fluorescence-tagged PatL1 protein accumulated in distinct foci that correspond to P bodies, as they co-localized with the P body components Lsm1, Rck/p54 and the decapping enzyme Dcp1.
In addition, as for its yeast counterpart, PatL1 expression was required for P body formation. Taken together, these data emphasize the conservation of important P body components from yeast to human cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Associated With Topoisomerase II Homolog 1 (PATL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Associated With Topoisomerase II Homolog 1 (PATL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Associated With Topoisomerase II Homolog 1 (PATL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Associated With Topoisomerase II Homolog 1 (PATL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Associated With Topoisomerase II Homolog 1 (PATL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Associated With Topoisomerase II Homolog 1 (PATL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Associated With Topoisomerase II Homolog 1 (PATL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Associated With Topoisomerase II Homolog 1 (PATL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Associated With Topoisomerase II Homolog 1 (PATL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Associated With Topoisomerase II Homolog 1 (PATL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Associated With Topoisomerase II Homolog 1 (PATL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Associated With Topoisomerase II Homolog 1 (PATL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Associated With Topoisomerase II Homolog 1 (PATL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Associated With Topoisomerase II Homolog 1 (PATL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Associated With Topoisomerase II Homolog 1 (PATL1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of PatL1, a human homolog to yeast P body component Pat1."Biochim. Biophys. Acta 1773:1786-1792(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates."Proc. Natl. Acad. Sci. U.S.A. 106:13517-13522(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies."Mol. Cell. Biol. 30:4308-4323(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Distinct functions of maternal and somatic Pat1 protein paralogs."RNA 16:2094-2107(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The human Pat1b protein: a novel mRNA deadenylation factor identified by a new immunoprecipitation technique."Nucleic Acids Res. 39:635-647(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor."Mol. Biol. Cell 23:213-224(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa."EMBO J. 29:2368-2380(2010) [PubMed] [Europe PMC] [Abstract]