Centrosomal Protein 97kDa (CEP97)

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LRRIQ2; Leucine-Rich Repeats And IQ Motif Containing 2

Centrosomal Protein 97kDa (CEP97)
Mammalian centrioles play a dynamic role in centrosome function, but they also have the capacity to nucleate the assembly of cilia. Although controls must exist to specify these different fates, the key regulators remain largely undefined. CP110, a protein that plays an essential role in centrosome duplication and cytokinesis, and have identified a previously uncharacterized protein, Cep97, that recruits CP110 to centrosomes. Depletion of Cep97 or expression of dominant-negative mutants results in CP110 disappearance from centrosomes, spindle defects, and polyploidy. Remarkably, loss of Cep97 or CP110 promotes primary cilia formation in growing cells, and enforced expression of CP110 in quiescent cells suppresses their ability to assemble cilia, suggesting that Cep97 and CP110 collaborate to inhibit a ciliogenesis program.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 97kDa (CEP97) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 97kDa (CEP97) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 97kDa (CEP97) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 97kDa (CEP97) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 97kDa (CEP97) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 97kDa (CEP97) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 97kDa (CEP97) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 97kDa (CEP97) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 97kDa (CEP97) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 97kDa (CEP97) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 97kDa (CEP97) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 97kDa (CEP97) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 97kDa (CEP97) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 97kDa (CEP97) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 97kDa (CEP97) ELISA Kit Customized Service Offer
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