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SH2 Domain Containing Protein 4A (SH2D4A)

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SH2A; PPP1R38; Protein phosphatase 1 regulatory subunit 38

SH2 Domain Containing Protein 4A (SH2D4A)
CCC R552
HGNC 26102
MGI 1919531
PubMed 19712589
RGD 1307991
UniProt Q9H788
Wiki SH2D4A
T cell-specific adapter (TSAd) protein and adapter protein in lymphocytes of unknown function (ALX) are two related Src homology 2 (SH2) domain-containing signaling adapter molecules that have both been shown to regulate TCR signal transduction in T cells. SH2D4Acontains an SH2 domain that is highly homologous to the TSAd protein and ALX SH2 domains and that shares other structural features with these adapters.
T cell development, homeostasis, proliferation, and function were all found to be normal in these mice. Furthermore, knockdown of SH2D4A expression in human T cells did not impact upon their function. SH2D4A is dispensable for TCR signal transduction in T cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH2 Domain Containing Protein 4A (SH2D4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH2 Domain Containing Protein 4A (SH2D4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH2 Domain Containing Protein 4A (SH2D4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH2 Domain Containing Protein 4A (SH2D4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH2 Domain Containing Protein 4A (SH2D4A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH2 Domain Containing Protein 4A (SH2D4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH2 Domain Containing Protein 4A (SH2D4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH2 Domain Containing Protein 4A (SH2D4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH2 Domain Containing Protein 4A (SH2D4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH2 Domain Containing Protein 4A (SH2D4A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH2 Domain Containing Protein 4A (SH2D4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH2 Domain Containing Protein 4A (SH2D4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH2 Domain Containing Protein 4A (SH2D4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH2 Domain Containing Protein 4A (SH2D4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH2 Domain Containing Protein 4A (SH2D4A) ELISA Kit Customized Service Offer
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  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A novel member of SH(2) signaling protein family: cloning and characterization of SH(2)A gene."Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:458-462(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
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  7. "Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells."J. Immunol. 181:2019-2027(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "SH2D4A regulates cell proliferation via the ERalpha/PLC-gamma/PKC pathway."BMB Rep. 42:516-522(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]