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Inositol Monophosphatase 3 (IMPA3)

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IMPAD1; gPAPP; Inositol Monophosphatase Domain Containing 1; Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; Myo-inositol monophosphatase A3

Inositol Monophosphatase 3 (IMPA3)
CCC R531
HGNC 26019
MGI 1915720
PubMed 24745619
RGD 1306455
UniProt Q9NX62
IMPA3 belongs to the inositol monophosphatase family, encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol.
Jaws also known as Impad1 was identified in an insertional mutagenesis screen for genes encoding secreted and transmembrane proteins essential for mammalian development. The Jaws/Impad1 locus encodes a predicted protein of ~39 kDa with an N-terminal hydrophobic domain and a consensus inositol monophosphatase catalytic motif.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Monophosphatase 3 (IMPA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Monophosphatase 3 (IMPA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Monophosphatase 3 (IMPA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Monophosphatase 3 (IMPA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Monophosphatase 3 (IMPA3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Monophosphatase 3 (IMPA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Monophosphatase 3 (IMPA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Monophosphatase 3 (IMPA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Monophosphatase 3 (IMPA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Monophosphatase 3 (IMPA3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Monophosphatase 3 (IMPA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Monophosphatase 3 (IMPA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Monophosphatase 3 (IMPA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Monophosphatase 3 (IMPA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Monophosphatase 3 (IMPA3) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation."Proc. Natl. Acad. Sci. U.S.A. 105:11605-11612(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  5. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  6. "Chondrodysplasia and abnormal joint development associated with mutations in IMPAD1, encoding the Golgi-resident nucleotide phosphatase, gPAPP."Am. J. Hum. Genet. 88:608-615(2011) [PubMed] [Europe PMC] [Abstract]