GUF1 GTPase Homolog (GUF1)
[Edit]GTPase Of Unknown Function 1; Elongation factor 4 homolog; Ribosomal back-translocase; Translation factor GUF1, mitochondrial
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GUF1, a gene encoding a novel evolutionarily conserved GTPase in budding yeast.GUF1 predicts a 586 amino acid GTPase of the elongation factor-type class. The predicted Guf1p protein bears striking sequence similarity to both LepA from Escherichia coli (43% identical) and LK1236.1 from Caenorhabditis elegans (42% identical). Analysis of both a guf1 delta deletion and a putative constitutive-activating mutant (GUF1HG) revealed that GUF1 is not essential nor did mutant cells reveal any marked phenotype. Guf1, is located in the mitochondrial matrix and tightly associated with the inner membrane. It binds to mitochondrial ribosomes in a GTP-dependent manner. Mutants lacking Guf1 show cold- and heat-sensitive growth defects on non-fermentable carbon sources that are especially pronounced under nutrient-limiting conditions.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant GUF1 GTPase Homolog (GUF1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to GUF1 GTPase Homolog (GUF1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to GUF1 GTPase Homolog (GUF1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for GUF1 GTPase Homolog (GUF1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for GUF1 GTPase Homolog (GUF1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant GUF1 GTPase Homolog (GUF1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to GUF1 GTPase Homolog (GUF1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to GUF1 GTPase Homolog (GUF1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for GUF1 GTPase Homolog (GUF1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for GUF1 GTPase Homolog (GUF1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant GUF1 GTPase Homolog (GUF1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to GUF1 GTPase Homolog (GUF1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to GUF1 GTPase Homolog (GUF1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for GUF1 GTPase Homolog (GUF1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for GUF1 GTPase Homolog (GUF1) | ELISA Kit Customized Service Offer |
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]