Pentatricopeptide Repeat Domain Protein 2 (PTCD2)
[Edit]Pentatricopeptide repeat-containing protein 2, mitochondrial
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Mice homozygous for a defect in the PTCD2 (pentatricopeptide repeat domain protein 2) gene were generated in order to study the role of this protein in mitochondrial RNA metabolism. These mice displayed specific but variable reduction of ubiquinol–cytochrome c reductase complex activity in mitochondria of heart, liver and skeletal muscle due to a decrease in the expression of mitochondrial DNA-encoded cytochrome b, the catalytic core of the complex.
PTCD2 protein is involved in processing RNA transcripts involving cytochrome b derived from mitochondrial DNA. This defines the site for PTCD2 action in mammalian mitochondria and suggests a possible role for dysfunction of this protein in the aetiology of heart failure.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pentatricopeptide Repeat Domain Protein 2 (PTCD2) | ELISA Kit Customized Service Offer |
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Disruption of a mitochondrial RNA-binding protein gene results in decreased cytochrome b expression and a marked reduction in ubiquinol-cytochrome c reductase activity in mouse heart mitochondria."Biochem. J. 416:15-26(2008) [PubMed] [Europe PMC] [Abstract]