Centrosomal Protein 76kDa (CEP76)

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C18orf9

Centrosomal Protein 76kDa (CEP76)
Centrosomes duplicate only once per cell cycle, but the controls that govern this process are largely unknown. Cep76, a centriolar protein that interacts with CP110. Cep76 is expressed at low levels in G1 and is induced in S and G2 phase, during which point centrioles have already commenced duplication. Interestingly, depletion of Cep76 drives the accumulation of centriolar intermediates in certain types of cancer cells. Enforced Cep76 expression specifically inhibits centriole amplification in cells undergoing multiple rounds of duplication without preventing the formation of extra procentrioles from a parental template. Furthermore, elevated levels of Cep76 do not affect normal centriole duplication. Thus, Cep76 helps limit duplication to once per cell cycle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 76kDa (CEP76) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 76kDa (CEP76) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 76kDa (CEP76) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 76kDa (CEP76) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 76kDa (CEP76) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 76kDa (CEP76) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 76kDa (CEP76) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 76kDa (CEP76) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 76kDa (CEP76) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 76kDa (CEP76) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Centrosomal Protein 76kDa (CEP76) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 76kDa (CEP76) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 76kDa (CEP76) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 76kDa (CEP76) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 76kDa (CEP76) ELISA Kit Customized Service Offer
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  8. "Cep76, a centrosomal protein that specifically restrains centriole reduplication."Dev. Cell 16:649-660(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]