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Anoctamin 10 (ANO10)

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TMEM16K; Transmembrane protein 16K

Anoctamin 10 (ANO10)
CCC R430
HGNC 25519
MGI 2143103
PubMed 21092923
RGD 1308260
UniProt Q9NW15
Prioritization of all detected sequence variants led to four candidate genes, one of which contained a variant with a high base pair conservation score. This variant was a leucine-to-arginine substitution in the DUF 590 domain of a 16K transmembrane protein, a putative calcium-activated chloride channel encoded by anoctamin 10 (ANO10).
The analysis of ANO10 by Sanger sequencing revealed three additional mutations: a homozygous mutation in a Serbian family and a compound-heterozygous splice-site mutation and a frameshift mutation in a French family. This illustrates the power of using initial homozygosity mapping with next-generation sequencing technology to identify genes involved in autosomal-recessive diseases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anoctamin 10 (ANO10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anoctamin 10 (ANO10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 10 (ANO10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 10 (ANO10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 10 (ANO10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anoctamin 10 (ANO10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anoctamin 10 (ANO10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 10 (ANO10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 10 (ANO10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 10 (ANO10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anoctamin 10 (ANO10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anoctamin 10 (ANO10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 10 (ANO10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 10 (ANO10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 10 (ANO10) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Expression and function of epithelial anoctamins."J. Biol. Chem. 285:7838-7845(2010) [PubMed] [Europe PMC] [Abstract]
  5. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Anoctamins."Pflugers Arch. 462:195-208(2011) [PubMed] [Europe PMC] [Abstract]
  7. "ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins."Am. J. Physiol. 302:C482-C493(2012) [PubMed] [Europe PMC] [Abstract]
  8. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
  9. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Anoctamins are a family of Ca2+ activated Cl- channels."J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Targeted next-generation sequencing of a 12.5 Mb homozygous region reveals ANO10 mutations in patients with autosomal-recessive cerebellar ataxia." Am. J. Hum. Genet. 87:813-819(2010) [PubMed] [Europe PMC] [Abstract]