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Ataxin 7 Like Protein 3 (ATXN7L3)

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SAGA-associated factor 11 homolog

Ataxin 7 Like Protein 3 (ATXN7L3)
CCC R412
HGNC 25416
MGI 3036270
PubMed 18206972
UniProt Q14CW9
ATXN7L3 belongs to the SGF11 family. Component of some SAGA transcription coactivator-HAT complex, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitinylation. Interacts directly with ENY2 and USP22.
A putative ataxin-7 yeast orthologue (SGF73) has been identified recently as a new component of the SAGA (Spt/Ada/Gcn5 acetylase) multisubunit complex, a coactivator required for transcription of a subset of RNA polymerase II-dependent genes. ataxin-7 is the human orthologue of the yeast SAGA SGF73 subunit and is a bona fide subunit of the human TFTC-like transcriptional complexes. Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ataxin 7 Like Protein 3 (ATXN7L3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ataxin 7 Like Protein 3 (ATXN7L3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ataxin 7 Like Protein 3 (ATXN7L3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ataxin 7 Like Protein 3 (ATXN7L3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ataxin 7 Like Protein 3 (ATXN7L3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ataxin 7 Like Protein 3 (ATXN7L3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ataxin 7 Like Protein 3 (ATXN7L3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ataxin 7 Like Protein 3 (ATXN7L3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ataxin 7 Like Protein 3 (ATXN7L3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ataxin 7 Like Protein 3 (ATXN7L3) ELISA Kit Customized Service Offer
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing."Mol. Cell 29:92-101(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements."Mol. Cell. Biol. 31:3734-3744(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties."EMBO Rep. 11:612-618(2010) [PubMed] [Europe PMC] [Abstract]